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KMID : 1137820210420030071
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의공학회지
2021 Volume.42 No. 3 p.71 ~ p.79
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Radiomics-based Machine Learning Approach for Quantitative Classification of Spinal Metastases in Computed Tomography
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Lee Eun-Woo
Lim Sang-Heon
Jeon Ji-Soo
Kang Hye-Won
Kim Young-Jae
Jeon Ji-Young
Kim Kwang-Gi
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Abstract
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Currently, the naked eyes-based diagnosis of bone metastases on CT images relies on qualitative assessment. For this reason, there is a great need for a state-of-the-art approach that can assess and follow-up the bone metastases with quan?titative biomarker. Radiomics can be used as a biomarker for objective lesion assessment by extracting quantitative numerical values from digital medical images. In this study, therefore, we evaluated the clinical applicability of non-invasive and objective bone metastases computer-aided diagnosis using radiomics-based biomarkers in CT. We employed a total of 21 approaches consist of three-classifiers and seven-feature selection methods to predict bone metastases and select biomarkers. We extracted three?dimensional features from the CT that three groups consisted of osteoblastic, osteolytic, and normal-healthy vertebral bodies. For evaluation, we compared the prediction results of the classifiers with the medical staff's diagnosis results. As a result of the three?class-classification performance evaluation, we demonstrated that the combination of the random forest classifier and the sequen?tial backward selection feature selection approach reached AUC of 0.74 on average. Moreover, we confirmed that 90-percentile, kurtosis, and energy were the features that contributed high in the classification of bone metastases in this approach. We expect that selected quantitative features will be helpful as biomarkers in improving the patient's survival and quality of life.
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KEYWORD
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Radiomics, Machine learning, Spinal metastases, Quantitative biomarker, Computer-aided diagnosis
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